Posts tagged ‘Pangs’

Role of Chantix and Nicotine Receptors to Quit Smoking

Developed by Pfizer pharmaceuticals, Chantix Varenicline is an FDA approved drug used for smoking cessation. In numerous clinical trials Chantix has been proven to be the most effective quit smoking drug available on the market. The active ingredient in Chantix is called varenicline tartrate. It is a new form of medication that helps you quit smoking by relieving you of nicotine withdrawal pangs and reducing the pleasure derived from smoking. A 12-week Chantix treatment can quadruple your odds of quitting as against those who try to quit via the cold turkey method. Since, Chantix is a prescription only smoking cessation drug, you should use this medication after consulting a doctor.

Is nicotine highly addictive?

Nicotine addiction is the foremost reason why many people find it hard to quit smoking. According to World Health Organization (WHO), nicotine is highly addictive, in fact as addictive as heroine or cocaine. Within 7 to 10 seconds of inhaling cigarette smoke, the nicotine is carried deep into your lungs where it is absorbed quickly into the bloodstream and carried throughout your body, including the heart and blood vessels, the endocrine and the metabolic systems, as well as the brain. Once inside these systems, nicotine triggers a number of chemical reactions to render temporary feelings of pleasure for the smoker which subside within minutes. As the nicotine levels drop in the blood, the smokers feel the urge to light up again. They feel uncomfortable and agitated until they smoke again; this is owing to the nicotine withdrawal pangs. In order to relieve the nicotine withdrawal symptoms, smokers light one cigarette after another. Eventually, they become hooked to nicotine. After some time, this addiction becomes so strong that smokers find it extremely difficult to get over it.

How Chantix works as an agonist of nicotinic acetylcholine receptor?

Varenicline, the active ingredient in Chantix works as a partial agonist of the alpha4beta2 nicotinic acetylcholine receptor. In addition it acts on alpha3beta4 and weakly on alpha3beta2 and alpha6-containing receptors. By acting as an agonist, Chantix helps to relieve nicotine withdrawal symptoms and reduces the rewarding properties of nicotine, thereby aiding smoking cessation.

Role of Chantix and nicotine receptors

Chantix varenicline does not contain nicotine but it acts on the nicotine receptors in the brain. By binding to these nicotine receptors, Chantix blocks the effects of nicotine at those sites, helping to prevent the pleasurable effects of smoking. Chantix doesn’t only bind to nicotine receptors, it also acts like nicotine; this helps to prevent nicotine withdrawal symptoms. This is scientifically known as “a partial agonist.” This means that Chantix also competitively binds to alpha4beta2 receptors blocking the ability of nicotine to stimulate the release of dopamine.

Nicotine and dopamine

Although to a lesser degree, nicotine activates the same reward pathways in the brain as do other drugs of abuse such as cocaine or amphetamine. When you smoke, the nicotine from your cigarette causes the receptors in your brain to release several chemicals, including dopamine – a neurotransmitter that is responsible for the feelings of pleasure and well-being. But, these pleasurable effects of nicotine wear off within minutes. You therefore feel the urge to smoke again to maintain the level of dopamine in your blood. However, when you quit smoking the lower levels of dopamine cause you to suffer from nicotine withdrawal symptoms which typically include irritability, insomnia and difficulty concentrating. Nicotine withdrawal symptoms begin 4 to 6 hours after your last cigarette and can last a month or more after you have quit smoking. Many people are not able to cope with these withdrawal pangs and therefore revert to smoking.

Chantix and dopamine

Chantix varenicline helps people fight off nicotine withdrawal symptoms with ease. Chantix imitates the effect of nicotine on the brain. It stimulates the release of low levels of dopamine and other chemicals in your brain to help reduce the signs and symptoms of withdrawal; therefore your body no longer craves nicotine. In addition, Chantix blocks the nicotine receptors in your brain. So if you lapse during your Champix treatment and have a cigarette, the nicotine in the smoke will fail to stimulate your brain’s receptors the way it did in the past. You therefore do not derive the same pleasure as you used to and as a result your desire to return to regular smoking again may be reduced.

Is Chantix effective?

Chantix varenicline is proven to be the most effective quit smoking drug currently available on the market. According to a 12-week clinical study, a 44% success rate was noticed amongst people taking the Chantix treatment as against 33% success rate amongst people using Zyban (bupropion), the only other FDA approved quit smoking drug. Further study which lasted for a year showed 22% abstinence amongst people using Chantix and 16% abstinence amongst people using Zyban. However, Chantix works best when used in conjunction with professional counseling.

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Way to Quit Smoking Right Now Without Thoose Nasty Withdraw Pangs


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Exercise and Smoking

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With all the gadgets and aids marketed today promising a quick fix to those looking to stop smoking, the truth can sometimes be hard to discern. Patches, gum, inhalers and hypnosis have all been used with some success, but none are foolproof, and they certainly don’t come cheap. There is another alternative though. Studies have shown that regular exercise performed either as a stand-alone method or in combination with nicotine replacement, can significantly curb your craving to smoke, and assist you in coping with the nasty withdrawal symptoms that can interfere with your life.

In a 2005 study in Vienna, 216 people were placed on nicotine replacement therapy for their cigarette addiction, and half of those – 108 – were asked to engage in at least 30 minutes of exercise a day. At the conclusion of the study, 40% of those receiving nicotine replacement alone had remained smoke free – a fairly good result-but a whopping 80% of those who had included exercise had achieved the same feat. That’s double! And with similar results being reported in studies around the world, many experts are now recognizing the powerful benefits of exercise for those who are trying to give up smoking.

Cessation from smoking is difficult, with many who attempt it complaining of physical withdrawal that is, at times, unbearable. Regular exercise can help significantly to ease the effects of these symptoms. One very good reason is that exercise will help take your mind off things.

Who wouldn’t be miserable simply sitting back and allowing the cravings to consume them? A jog on the treadmill or a walk in the woods can help take your mind off the uneasiness you feel, and serve as a healthy distraction for dealing with your cravings.

As a smoker, the thought of weight gain as a side effect of quitting can be a frightening deterrent. The cravings for cigarettes can sometimes resemble hunger pangs and may cause some to overindulge. With regular exercise, however, this is an easy problem to address.

Take some time at the gym to burn off those extra calories. Even if you do put on a few extra pounds, the heart healthy benefits of a consistent exercise program will more than make up for it.

Exercise, used as treatment for withdrawal, a method for shedding unwanted pounds or just as part of an overall healthy routine, can help you quit smoking and recover safely from your addiction. This book will outline the various health benefits for the ex-smoker and suggest exercise programs to both facilitate a smooth cessation from cigarettes and prevent weight gain.

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How to Quit Smoking Cigarettes Naturally ??

How to Quit Smoking Cigarettes Naturally – Learn How to Quit Smoking Cigarettes Naturally


So what if it is really that easy? What if all your beliefs about how hard it is going to be to quit are completely false? What if, after just one session of hypnotherapy or NLP you find it incredibly easy to become and remain a happy, confident non-smoker for life?

The reason why hypnotherapy & NLP are so successful is because both our beliefs about smoking and our habitual smoking behaviours reside within your unconscious mind. So whilst consciously we may wish to quit, all too often our all powerful unconscious mind simply would not let us.

You see when smokers first start
; they buy into years of conditioning telling them that smoking made them feel somehow better, more confident and more relaxed. And as a result of lighting up those first few cigarettes, smokers permanently install these extremely unhelpful beliefs directly into their unconscious, beliefs that also included the concept that quitting was going to be really difficult. 

At the same time, smokers make a conscious decision to choose those perceived benefits of feeling better, more relaxed and more confident, over the initial physical reactions of inhaling the poisonous fumes. So as time goes on and those uncomfortable physical reactions start to subside, as a result of their newly formed nicotine addiction, they started to mistake the relief of feeding that addiction with feelings of relaxation and confidence.

So many years later, after smoking tens of thousands (possibly hundreds of thousands) of cigarettes, they have re-enforced those unhelpful beliefs about smoking and how hard it is to quit and, they have also trained their unconscious minds to wrongly associate the process of lighting and smoking a cigarette with feeling good, confident and relaxed.

Hypnotherapy and NLP allow us to retrain the unconscious mind of a smoker to disregard those false beliefs about smoking and how hard it is to quit, and to swap those unconscious benefits for something altogether more exciting and fulfilling – feeling absolutely great!

So as a result, the all too familiar withdrawal pangs of irritability, mood swings and cravings, the primary reasons why people fail to permanently quit smoking, will be replaced with feelings of relaxation, improved self confidence and overall happiness.

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A Little Plan Can Help You Achieve Your Quit Smoking Goal

In their heart most smokers nurture a secret desire to quit smoking one day. However, most smokers, especially those who have been addicts for years feel jittery about the idea of quitting. They become so attached to their cigarettes that they find it hard to imagine their life without them. Further, the idea of suffering from nicotine withdrawal symptoms also dissuades them from even thinking of smoking cessation. It is only when the harmful effects of smoking begin to take a toll on their health that a smoker develops the will to quit smoking. At this stage, a lot of damage may already have been done and the people may find it extremely hard to quit as they cannot stay without their cigarettes. Hence, you should begin early and remain motivated to achieve your smoking cessation goal.

Smoking is harmful – Motivate yourself to quit

Experts believe, that smokers should embark on a quit smoking plan as early as possible. This is because smoking is associated with numerous life-threatening conditions including heart diseases, various types of cancers and lung ailments. Further, smoking adversely affects the health of your family members and friends through passive smoking. Pregnant ladies who smoke are likely to suffer from miscarriages or give birth to low birth weight babies. Further, there are many other social consequences of smoking. People try to avoid the company of those who smoke. Addicts tend to smell bad and their appearance also changes since their skin and teeth are adversely affected due to the effects of harmful chemicals contained in cigarette smoke. The best way to avoid the harmful effects of smoking is to quit as early as possible.

Develop a positive mindset to quit

This world is a beautiful place and you’ll certainly not like to leave it early because of a smoking related condition. Neither is it the best way to quit this world. Wouldn’t it be better to quit smoking and spend your days in this world happy and healthy? A positive approach towards smoking cessation will help you achieve your quit smoking goals successfully.

Having the right mindset is crucial to the success of any program, including smoking cessation. Many people have successfully quit smoking without any counseling or use of any of the quit smoking medications or aids; they have achieved this solely through their strong will-power and their determination to quit. You too need to nurture a strong and sincere desire to quit. Just think of how disturbed your family gets because of your smoking habits, imagine how much happiness you’ll bring to their life with your decision to quit smoking.

Choose your quit date

Experts believe that the right approach to begin your smoking cessation program is to pre-determine a quit date. This will bring more seriousness in your efforts. Choose this date wisely. Do not begin your program on days when you experience extraordinary stress. This is likely to trigger your temptation to start smoking and de-motivate you before you can complete your smoking cessation program. You may choose special days in your life as your quit smoking date such as your birthday or that of your loved one. Alternatively, you may choose Christmas or New Year depending on your convenience. Mark this date on your calendar and inform your friends about your quit smoking date. Request them to support you in your quit smoking endeavors; with their help you can get over the withdrawal symptoms.

Make preparations to quit smoking

Success of your smoking cessation goal depends a lot on your preparation to quit smoking. Invest sometime in preparing to quit smoking. Before your quit date hide away all your ashtrays and lighters and throw away all the cigarettes that may be lying around your home or workplace. Remove everything that could be a reminder of your smoking days. Also, identify your smoking triggers. Once you are set on your smoking cessation program try to avoid people and situations that tempt you to smoke. Another good idea would to develop a hobby or to spend more time doing things that interest you. This will keep your mind away from the thoughts of smoking. Eat a balanced diet and participate in regular physical exercise to keep a positive mindset. This is essential since nicotine withdrawal symptoms make you feel irritated, anxious and depressed. In addition, you may consult a doctor to know if you should make use of smoking cessation aids to relieve you of nicotine withdrawal symptoms and help you quit successfully.

Quit smoking aids that you may use

Discussed below are some of the most popular quit smoking aids that will help relieve you of nicotine withdrawal symptoms effectively –

  • Quit smoking treatment – Nicotine replacement therapy (NRT)
  • This effective therapy aims at providing nicotine to the body externally. It helps to relieve you of withdrawal pangs so that you are able to get out of the habit of smoking. The NRTs are available in various forms including nicotine chewing gum, nicotine patches, nicotine tabs, lozenges, nicotine nasal spray and inhalators. However, since NRTs provide nicotine to your body, a risk of re-addiction is involved in this therapy.

  • Stop smoking treatment – Chantix & Zyban
  • Currently, nicotine-free quit smoking medications such as Zyban (bupropion hydrochloride) and Chantix (varenicline tartrate) are the most popular quit smoking aids. These medicines are approved by the FDA as smoking cessation drugs and are available on a prescription only. Both Chantix and Zyban imitate the effect of nicotine on your brain to stimulate the release of dopamine – a neurotransmitter that gives you the feeling of pleasure; you therefore do not experience a craving for cigarettes. In addition, Chantix prevents nicotine from acting on its receptors on the brain. This means that even if you give in to the temptation to smoke again you’ll not derive the same pleasure and therefore you’ll no longer be tempted to light up again.

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How does Nicotine Replacement Therapy Work?

Nicotine Replacement Therapy, or NRT, works by fulfilling your body’s need for nicotine. This can make it easier to quit smoking, because you don’t feel cravings for the drug as you’re quitting. Read on to learn more about the various forms NRT comes in and which is best for you.

The most common delivery method is via gum. It comes in both 4mg and 2mg variants, and is used similarly to chewing gum, except that after chewing it for a few minutes, you’re supposed to squeeze it against your gums so that you can absorb more of the nicotine. The 4mg dosage is for heavy smokers, and the 2mg one is for light (under 20/day usually) smokers.

This creates an up and down supply of the drug which closely mimics the way it normally is for a smoker. This, combined with the oral stimulation that comes from chewing the gum, can make the gum a great way to quit.

Another common form is the patch. Applied to the surface of the skin on the upper body, it causes nicotine to be absorbed through the skin, creating a steady supply of nicotine. Over time, the dosage is ramped down until you don’t need the drug at all any more.

While it seems counter-intuitive, the constant flow of nicotine from the patch makes it so you don’t feel the withdrawal pangs that cause most quit attempts to fail. It makes it a lot easier to quit because your nicotine supply is already taken care of and you don’t have to worry about anything other than normal everyday tasks.

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